English: What is intrarenal acute kidney injury? Acute kidney injury (AKI) describes when the kidneys aren't functioning optimally, usually brought about within a few days. Intrarenal causes could be damage to the tubules as in acute tubular necrosis, the glomerulus as in glomerulonephritis, or the interstitium as in acute interstitial nephritis. This video discusses the pathophysiology, as well as several common mechanisms and causes for intrarenal AKI.